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Glaciol., 39, 4148, 2004

Furthermore, when combined with synephrine, which activates the 2-adrenergic receptor (2-AR) causing relaxation of bronchial smooth muscle, stachydrine enhances the bronchodilatory effect of synephrine, thus improving its efficacy in reducing airway spasms and supporting its use in asthma treatment (Shi et al., 2009)

The epoxide is then activated by the hydrogen bond with the tyrosine residues and opened by a nucleophilic attack of the aspartate (which is orientated and activated by a histidine residue, a second carboxylic acid amino acid, and potentially other amino acids located in the catalytic center) on one of the epoxide carbons forming an enzyme-substrate ester intermediate

All authors critically revised the manuscript and agree to be fully accountable for ensuring the integrity and accuracy of the work and read and approved the final manuscript

general practice and non-academic referral veterinary surgeons are often unsure of when to recommend supplementation